Figure 2. The pathological muscular dystrophy traits of membrane leak and fibrosis independently map to the dMOD1 locus on chromosome 7.

(A) lod scores are shown for 328 SNPs for the trait of membrane leak (dye uptake) in the quadriceps muscles. dMOD1 maps to chromosome 7 with a peak lod of 10.17. (B) lod scores across the genome correlated to fibrosis (HOP content) also map to the dMOD1 on chromosome 7 with a peak lod score of 6.95. Chromosomes and SNP positions are indicated on the x axis, and lod scores are on the y axis. The percentages indicate the chance that this event occurred non-randomly. The right panels show lod scores derived from fine mapping of chromosome 7 near dMOD1, with a peak lod score for dye uptake and fibrosis of 13.52 and 11.32, respectively. (C) The degree of membrane leak and fibrosis correlate. Measurements from quadriceps muscle of membrane leak (dye uptake) and fibrosis (HOP content) were plotted (r² = 0.1029; P < 0.005).