Figure 7. Th22 cells influence keratinocyte functions by a combination of IL-22 and TNF-α.

Human primary keratinocytes were stimulated with Th22 supernatants in the presence or absence of neutralizing anti–IL-22 antibodies (left) or with recombinant cytokines (right). mRNA was extracted after 12 hours, and gene expression was analyzed by real-time PCR. (A) Chemokine expression. (B) Innate immune response. (C) Cytokine expression pattern. Data are representative for at least 3 independent experiments. Error bars indicate SD.