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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Heart Fail Clin. 2010 Jan;6(1):55–64. doi: 10.1016/j.hfc.2009.08.007

Figure 2.

Figure 2

The corin I555(P568) minor allele is comprised of two single nucleotide polymorphisms that are in complete linkage disequilibrium in African-Americans with an allelic prevalence of 6%. The SNPs result in a T555I and Q568P amino acid change within the second cysteine-rich, frizzled domain in corin. These amino acid changes are biochemically non-conservative and demonstrate strong conservation. Because of the linkage disequilibrium, the SNPs travel on the same parental chromosome are the two resulting amino acid changes will be transcribed into the same corin molecule in heterozygous carriers of the corin I555(P568) minor allele.