TABLE 1.

Summary of actions of GRP78 in different virus infections

Virus	Production of virala:						GRP78 chaperone role
	RNA	Intracellular protein	Protein maturation and structure	Intracellular particles	Extracellular particles	Extracellular infectious virus
DENV	√	X	ND	X	ND	X	Protein production
HCMVb	ND	√	ND	√	X	X	Particle egress
Rotavirusc	ND	√	X	ND	√d	X	Correct protein structure and maturation

^aThe columns indicate the stage of virus infection that is unaffected (√) or inhibited (X) when GRP78 is reduced. ND, not determined.

^bReference 3.

^cReference 25.

^dThe total amount of extracellular virus is also reduced.