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Model of recruitment of TAP to EB2-containing mRNPs. (A) EB2 first interacts with its target mRNA and recruits REF into the mRNP. (B) TAP recruited by REF onto the mRNP interacts with EB2 at a low affinity. (C) TAP is transferred to the mRNA following its interaction with REF and changes its conformation, thereby interacting with EB2 at a higher affinity.
