. 2009 Nov 17;101(23):1624–1632. doi: 10.1093/jnci/djp386

Table 3.

Associations of patient-reported or clinician-reported symptoms and performance status with risk of death or risk of ER admission (n = 163)^*

Threshold	Reporter	Risk of death		Risk of ER admission		% Reaching threshold before death	% Dying who reached threshold
Threshold	Reporter	HR (95% CI)	P	HR (95% CI)	P	% Reaching threshold before death	% Dying who reached threshold
Fatigue
Moderate	Patient	1.46 (0.79 to 2.69)	.23	1.18 (0.75 to 1.83)	.48	71	46
Moderate	Clinician	2.75 (1.54 to 4.91)	<.001	1.87 (1.23 to 2.86)	.004	66	48
Severe	Patient	1.44 (0.89 to 2.37)	.15	^†	^†	37	48
Severe	Clinician	2.39 (1.43 to 4.46)	.003	^†	^†	17	57
Nausea^†
Moderate	Patient	1.27 (0.74 to 2.18)	.38	^†	^†	33	45
Moderate	Clinician	2.07 (1.18 to 3.63)	.01	^†	^†	16	65
Constipation^†
Moderate	Patient	1.26 (0.74 to 2.13)	.40	1.53 (0.95 to 2.45)	.08	28	47
Moderate	Clinician	1.68 (1.03 to 2.75)	.038	1.28 (0.82 to 2.00)	.28	39	48
KPS
Score ≤80	Patient	1.48 (0.92 to 2.51)	.13	1.27 (0.84 to 1.910)	.26	55	46
Score ≤80	Clinician	4.91 (2.89 to 8.38)	<.001	1.68 (1.07 to 2.62)	.02	48	59
Score ≤70	Patient	1.40 (0.84 to 2.35)	.20	^†	^†	28	48
Score ≤70	Clinician	6.39 (3.88 to 11.08)	<.001	^†	^†	18	77
Pain
Moderate	Patient	1.47 (0.89 to 2.41)	.13	1.44 (0.95 to 2.180)	.09	50	47
Moderate	Clinician	1.56 (0.94 to 2.59)	.08	1.84 (1.22 to 2.76)	.004	47	51
Severe	Patient	2.18 (1.22 to 3.89)	.008	1.71 (0.97 to 2.99)	.06	24	56
Severe	Clinician	2.29 (1.39 to 3.78)	.001	1.67 (1.05 to 2.68)	.03	29	61

CI = confidence interval; ER = emergency room; HR = hazard ratio; KPS = Karnofsky Performance Status. P values (two-sided) were generated by using the two-sided Wald test for parameter estimates.

^†

Too few deaths among patients reaching severe nausea or constipation thresholds, and too few ER admissions among patients reaching severe fatigue, moderate or severe nausea, severe constipation, or KPS 70 or less thresholds to conduct analyses.