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Simplified schemata of relevant proteins involved in intracellular calcium (iCa) regulation. Coupling of myocyte excitation-contraction is mediated through calcium (Ca), initiated by the inward L-type Ca channel. This current leads to sarcoplasmic reticulum (SR) release of Ca via the ryanodine receptor type 2 (RyR2) and the subsequent contractile process. βAR Beta-adrenergic receptor; cAMP Cyclic AMP; Na Sodium; PKA Protein kinase A; SERCA2a Sarcoplasmic reticulum calcium ATPase-2a
