TABLE 2.
Studies demonstrating a relationship between endothelial function and prognosis
| Author | Patient population | Conclusions |
|---|---|---|
|
Coronary vasomotion | ||
| Al Suwaidi et al (38) | Mild coronary atherosclerosis (n=157) | Predictive of increased rates of myocardial events |
| Schachinger et al (49) | Chest pain (n=147) | Independently predictive of increased rates of myocardial events |
| Hollenberg et al (59) | Postcardiac transplant (n=73) | Predictive of CV events |
| Halcox et al (60) | Patients with and without CAD (n=308) | Independent predictor of CV events |
| Targonski et al (61) | Patients with mild CAD (n=503) | Independent predictor of cerebrovascular events |
|
Impedance plethysmography | ||
| Perticone et al (14) | Untreated hypertensives (n=225) | Predictive of increased rates of myocardial events in step-wise modelling |
| Heitzer et al (42) | Patients with CAD (n=281) | Independent predictor of CV events |
| Fichtlscherer et al (62) | Patients with ACS (n=198) | Response to acetylcholine predictive of events |
|
Flow-mediated dilation | ||
| Modena et al (10) | Post-menopausal female hypertensives (n=400) | Lack of improvement in endothelial dysfunction with antihypertensives associated with CV events |
| Rossi et al (15) | Postmenopausal women (n=2264) | FMD predictive of CV events beyond traditional risk factors |
| Yeboah et al (51) | Elderly cohort (n=2792) | FMD predictive of CV events beyond traditional risk factors |
| Gokce et al (63) | Elective vascular surgery patients (n=187) | FMD independently predictive of CV events |
| Brevetti et al (64) | Patients with peripheral vascular disease (n=131) | ABI predictive of CV events |
| Chan et al (65) | Patients in cardiac rehabilitation (n=152) | FMD associated with CV events |
| Karatzis et al (66) | Patients with NSTEMI (n=98) | FMD independently predictive of CV events |
| Patti et al (17) | Patients postcoronary stent (n=136) | FMD predictive of restenosis |
| Shimbo et al (52) | Multiethnic population with varied levels of risk (n=842) | FMD predictive of outcomes, but not in multivariate analysis |
|
Reactive hyperemia | ||
| Huang et al (16) | Vascular surgery patients (n=267) | RH and FMD independently predictive of CV events beyond traditional risk factors |
Table adapted from Mancini (58). ABI Ankle-brachial index; ACS Acute coronary syndrome; CAD Coronary artery disease; CV Cardiovascular; FMD Flow-mediated dilation; NSTEMI Non-ST elevation myocardial infarction; RH Reactive hyperemia