Table 3.
CYP1A1 single nucleotide polymorphisms (SNPs) and childhood leukemia risk
| All leukemia |
ALL |
||||
|---|---|---|---|---|---|
| Controls (n = 164) | Cases (n = 164) | OR (95% CI)a | Cases (n = 106) | OR (95% CI)a | |
| –17961T>C | |||||
| CC | 81 (50.0) | 68 (43.3) | Ref. | 40 (39.2) | Ref. |
| CT | 61 (37.7) | 66 (42.0) | 1.3 (0.8–2.1) | 49 (48.0) | 1.6 (0.9–2.8) |
| TT | 20 (12.3) | 23 (14.7) | 1.3 (0.7–2.8) | 13 (12.8) | 1.4 (0.6–3.1) |
| CT/TT | 81 (50.0) | 89 (56.7) | 1.3 (0.8–2.1) | 62 (60.9) | 1.6 (0.9–2.6) |
| –9893G>A | |||||
| GG | 87 (54.4) | 90 (57.0) | Ref. | 59 (58.4) | Ref. |
| GA | 64 (40.0) | 59 (37.3) | 0.9 (0.6–1.4) | 36 (35.6) | 0.8 (0.5–1.4) |
| AA | 9 (5.6) | 9 (5.7) | 1.0 (0.4–2.8) | 6 (5.9) | 1.0 (0.3–3.0) |
| GA/AA | 73 (45.6) | 68 (43.0) | 0.9 (0.6–1.4) | 42 (41.6) | 0.8 (0.5–1.4) |
| Ex7+131A>G (I462V) | |||||
| AA | 85 (53.5) | 90 (56.3) | Ref. | 60 (57.1) | Ref. |
| AG | 65 (40.9) | 61 (38.1) | 0.9 (0.5–1.4) | 39 (37.1) | 0.9 (0.5–1.5) |
| GG | 9 (5.7) | 9 (5.6) | 1.0 (0.4–2.7) | 6 (5.7) | 0.9 (0.3–2.7) |
| AG/GG | 74 (46.5) | 70 (43.8) | 0.9 (0.6–1.4) | 45 (42.9) | 0.9 (0.5–1.5) |
| 1188C>T | |||||
| TT | 56 (34.6) | 58 (36.2) | Ref. | 34 (33.3) | Ref. |
| TC | 74 (45.6) | 80 (50.0) | 0.9 (0.6–1.6) | 56 (54.9) | 1.1 (0.6–2.0) |
| CC | 32 (19.8) | 22 (13.8) | 0.7 (0.3–1.3) | 12 (11.8) | 0.6 (0.3–1.3) |
| TC/CC | 106 (65.4) | 102 (63.8) | 0.9 (0.5–1.4) | 68 (66.7) | 1.0 (0.6–1.7) |
| 11599C>G | |||||
| CC | 53 (32.5) | 39 (24.4) | Ref. | 25 (24.3) | Ref. |
| CG | 69 (42.3) | 80 (50.0) | 1.6 (0.9–2.8) | 54 (52.4) | 1.8 (1.0–3.3) |
| GG | 41 (25.2) | 41 (25.6) | 1.4 (0.7–2.5) | 24 (23.3) | 1.3 (0.6–2.7) |
| CG/GG | 110 (67.5) | 121 (75.6) | 1.5 (0.9–2.5) | 78 (75.7) | 1.6 (0.9–2.8) |
| Haplotypeb | All leukemia |
ALL |
|||
|---|---|---|---|---|---|
| Controls (%) | Cases (%) | OR (95% CI)a | Cases (%) | OR (95% CI)a | |
| TGATG | 29.5 | 34.4 | Ref. | 35.2 | Ref. |
| CAGCC | 23.8 | 22.0 | 0.8 (0.5–1.2) | 21.4 | 0.7 (0.4–1.2) |
| CGATG | 17.9 | 16.6 | 0.8 (0.5–1.4) | 14.8 | 0.7 (0.4–1.3) |
| CGACC | 14.7 | 12.1 | 0.7 (0.4–1.2) | 12.2 | 0.6 (0.3–1.2) |
| CGATC | 10.9 | 11.4 | 1.0 (0.5–1.7) | 12.2 | 0.9 (0.5–1.7) |
| Rare haplotypes | 3.2 | 3.5 | 4.2 | ||
| Pomnibusc | 0.61 | 0.46 | |||
a
Adjusted for age of child, gender, father's education, and birth weight.
b
Composed of –17961T>C, –9893G>A, Ex7+13A>G (I462V), 1188C>T, and 11599C>G.
c
Omnibus test for overall distribution of haplotypes.