Skip to main content
. Author manuscript; available in PMC: 2009 Dec 2.
Published in final edited form as: J Child Neurol. 2007 Aug;22(8):967–973. doi: 10.1177/0883073807305664

Figure 3.

Figure 3

Osteoclast stimulatory factor and SMN protein interactions in osteoclasts. Osteoclast stimulatory factor contains a proline-rich sequence at the amino terminus, followed by an SH3 domain and ankyrin repeats. Osteoclast stimulatory factor interacts with c-Src through a proline-rich sequence. Osteoclast stimulatory factor SH3 domain binds to SMN at the exon 6 encoding region. Osteoclast stimulatory factor and SMN signaling release soluble factors that stimulate osteoclast formation and survival.17