Table 3.
Associations between ADH genotypes and breast cancer risk in Washington County, MD
| Genotypes | Controls N=321 |
Controls N=321 |
Adjusted OR1 (95% CI2) |
|---|---|---|---|
| Functional | |||
| DH1C (Ex8-56A>G) | |||
| 2,2 | 50 | 60 | 1.00 (ref) |
| 1,2 | 133 | 137 | 1.14 (0.73,1.78) |
| 1,1 | 120 | 115 | 1.18 (0.75,1.86) |
| 1,2/1,1 | 253 | 252 | 1.16 (0.77,1.76) |
| Missing | 18 | 9 | |
| P trend = 0.50 | |||
| ADH1C (Ex6-14G>A) | |||
| 2,2 | 29 | 39 | 1.00 (ref) |
| 1,2 | 100 | 105 | 1.24 (0.71,2.17) |
| 1,1 | 98 | 99 | 1.21 (0.69,2.13) |
| 1,2/1,1 | 198 | 204 | 1.23 (0.73,2.07) |
| Missing | 94 | 78 | |
| P trend = 0.62 | |||
| ADH1B (Ex3− +23 A >G) | |||
| 1,1 | 246 | 270 | 1.00 (ref) |
| 1,2 | 14 | 10 | 1.43 (0.62,3.34) |
| 2,2 | 1 | 0 | N/A |
| 1,2/2,2 | 15 | 10 | 1.55 (0.68,3.56) |
| Missing | 60 | 41 | |
| P trend = 0.24 | |||
| Other | |||
| ADH1C (IVS6 +10G>A) | |||
| G,G | 101 | 101 | 1.00 (ref) |
| A,G | 103 | 100 | 1.03 (0.69,1.53) |
| A,A | 48 | 35 | 0.79 (0.47,1.34) |
| A,G/A,A | 151 | 135 | 0.96 (0.66,1.38) |
| Missing | 69 | 85 | |
| P trend = 0.49 | |||
| ADH1B (IVSI +896A>G) | |||
| A,A | 96 | 106 | 1.00 (ref) |
| A,G | 117 | 108 | 0.87 (0.59,1.28) |
| G,G | 52 | 33 | 0.62 (0.37,1.04) |
| A,G/G,G | 169 | 141 | 0.79 (0.55,1.14) |
| Missing | 56 | 74 | |
| P trend = 0.08 | |||
1
O.R. = Odds ratio, adjusted for matching factors (baseline menopausal status and age).
2
CI = confidence interval. The rs numbers used by the NCI SNP 500 database (http://snp500cancer.nci.nih.gov/home) are as follows; ADH1CEx8-56A>G – rs 698, ADH1CEx6-14G>A - rs 1693482, ADH1B ( Ex3- +23 A >G – rs 1229984, ADH1CIVS6 +10G>A - rs 1789912, ADH1BIVSI +896A>G - rs 1353621.