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SHSY5Y cells, grown in the presence of 25 nM TMR-Aβ1–42 for 24 h, were imaged using confocal microscopy. The phase image of a group of cells is shown in the x-y plane with the fluorescence intensity plotted on the z axis and projected onto the image. The fluorescence originating from intracellular vesicles is up to two orders of magnitude greater than fluorescence in the extracellular medium (see Fig. S3 A and B), suggesting high effective concentrations of Aβ in the vesicles.
