Fig. 5.

Comparison of the behavioral effects of single versus dual inhibitors of FAAH and MAGL in a THC-appropriate drug discrimination assay. (A) JZL195 (40 mg·kg⁻¹, i.p.) produces THC-appropriate nose pokes at a magnitude similar to THC (5.6 mg·kg⁻¹, s.c.), which is reversed by rimonabant (3 mg·kg⁻¹, i.p.). (B) JZL184 (40 mg·kg⁻¹, i.p.) also shows full substitution for THC in FAAH(−/−) mice, but only incomplete (partial) substitution in FAAH(+/+) mice. For both A and B, an 80% cut-off was used to assign THC-appropriate responses. *, P < 0.05; ***, P < 0.001 for vehicle–vehicle versus vehicle–JZL195 or vehicle–JZL184 treated mice; #,P < 0.05; ###,P < 0.001; for vehicle–JZL195 or vehicle–JZL184 versus rimonabant–JZL195 or rimonabant–JZL184 treated mice, respectively. Data are presented as means ± SEM. n = 6–14 mice per group.