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Silvestrol induces apoptosis through the mitochondrial pathway. (A) LNCaP cells were treated with silvestrol as indicated in the figure. The cells were then sequentially stained with DiOC6 and propidium iodide followed by flow cytometric analysis. Note the leftward shift in the peaks silvestrol exposed cells relative to controls, which is indicative of mitochondrial membrane depolarization. (B) Immunoblot of the effect of silvestrol on cytochrome c, bak, and phosphorylated bcl-xl.
