Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
IC50 of compounds against Types I, II, & III PPCSs.
| hsPPCS (II) | efPPCS (III) | spPPCS (III) | ecPPCS (I) | |
|---|---|---|---|---|
| 3 | 10 μM (1) | 65 nM (9) | 10 nM (2) | 68 nM (9) |
| 4 | 2.7 mM (0.2) | 18 μM (4) | 13 μM (4) | 3.0 μM (0.3) |
| 7 | 200 μM (11) | 2.7 μM (0.2) | 3.9 μM (0.2) | 270 nM (3) |
| 8 | 5.9 mM (0.6) | 181 μM (7) | 279 μM (27) | 16 μM (5) |
hs=human, ef=E. faecalis, sp=S. pneumoniae, ec=E. coli. Assays were performed in triplicate. Standard error shown in ( ).
