Table 3. Contact residues for the eight selected small molecules. All residues contain are within 4 Å of a ligand atom. Residues in bold are common to all six ligands.

Residue	Transmembrane	TT3	SP50	SP46	SP40	SP45	CB28
Leu 92	TM2
Tyr 117	TM3		X	X	X	X
Phe 121	TM3	X	X	X	X	X
Tyr 122	TM3	X			X	X
Phe 126	TM3	X
Phe 167	TM4	X
Leu 201	TM5	X
Ser 202	TM5						X
Ser 203	TM5						X
Leu 204	TM5						X
Glu 205	TM5			X		X	X
Ile 206	TM5	X	X	X	X	X	X
Asn 207	TM5						X
Leu 209	TM5			X	X
Gly 210	TM5	X
Trp 255	TM6		X	X	X	X
Pro 257	TM6		X	X	X	X	X
Tyr 258	TM6	X	X	X	X	X	X
Asn 259	TM6	X					X
Ile 260	TM6						X
Val 261	TM6		X	X		X	X
Leu 262	TM6	X	X	X	X	X	X
Phe 263	TM6						X
Thr 266	TM6						X
Ala 285	EL3		X			X
Ile 286	EL3		X	X	X
Gln 287	EL3		X	X	X	X	X
Ala 288	TM7						X
Thr 289	TM7						X
Glu 290	TM7	X	X	X	X	X	X
Thr 291	TM7					X
Ala 293	TM7					X	X
Phe 294	TM7		X	X	X	X
Val 295	TM7		X	X	X	X