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Competitive reaction between GnT-III and GnT-V. Because GnT-III and GnT-V act on the same substrate but GnT-III acts on the substrate first and produces a bisecting GlcNAc structure, GnT-V is not able to act further. This leads to a suppression of the metastatic potential in vivo. Computer modeling of these reactions provided support for the this hypothesis.
