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Activation of ECE by PKC activators in SH-SY5Y cells (A) or cultured neurons (B). Bryostatin (Bryo; 0.27 nm), DCP-LA (1 μm), DHA-CP6 (1 μm), EPA-CP5 (1 μm), AA-CP4 (1 μm), or ethanol alone was added to cells growing on 12- or 24-well plates. After various periods of time, the cells were collected, and ECE activity was measured fluorometrically. *, p < 0.05; **, p < 0.001.
