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. 2009 Oct 16;284(50):34545–34552. doi: 10.1074/jbc.M109.056499

FIGURE 1.

FIGURE 1.

MTA1 physically interacts with p53. A, protein extracts from the wild-type p53-expressing U2OS or p53-null H1299 (negative control) cells were immunoprecipitated with an anti-p53 antibody or IgG control, and immunoblotted with the indicated antibodies. B, protein extracts from the MTA1+/+ or MTA1−/− (negative control) MEFs were immunoprecipitated with an anti-MTA1 antibody and immunoblotted with the indicated antibodies. C, diagrammatic summary of in vitro-translated MTA1 binding with a series of GST-p53 constructs. Trans, transactivation domain; Pro, proline-rich domain; DBD, DNA binding domain; Tetra, tetramerization domain; Reg, regulatory domain.