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Proposed model of CEM regulation of hyperoxia-mediated NADPH oxidase assembly and ROS production in human ECs. Hyperoxia treatment of human ECs induces c-Abl activation and c-Abl-mediated tyrosine phosphorylation of dynamin 2, which promotes p47phox-dynamin 2 interactions and recruitment of p47phox to CEMs. This recruitment promotes NADPH oxidase functional assembly and consequent ROS production.
