Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Dose response with urocortin and antalarmin on CRF(1–16)/R1ΔN and CRF(1–16[L8A])/R1ΔN. (a) CRF(1–16)/R1ΔN. (b) CRF(1–16[L8A])/R1ΔN. Data are presented as mean ± SD from triplicate determinations and are representative of three independent assays performed in parallel. For CRF(1–16)/R1ΔN, the IC50 for inhibition of constitutive activation by antalarmin is 14 ± 1 nM. For CRF(1–16[L8A])/R1ΔN, the EC50 for stimulation by urocortin is 140 ± 20 nM.
