TABLE 2.

SNPs associating with load phenotypes

Functional class	Gene	Location	Change	Ef female	Ef male	Ef all	Sm female	Sm male	Sm all	Ef SNP × Sex	Sm SNP × Sex
Signal	hopscotch	Exon	V → L	0.688	0.739	0.981	<0.001***	0.360	0.032*	0.172	0.946
Transduction							0.7		0.3
	hopscotch	Exon		<0.001***	0.025*	0.981	<0.001***	0.076*	<0.001***	<0.001***	0.022*
				0.4	0.5		0.8	0.2	0.4	6.2	0.9
	hopscotch	Exon		<0.001***	0.120	<0.001***	<0.001***	0.735	0.372	0.274	0.043*
				0.4		0.2	0.1				0.7
	hemipterous	Exon	Y → C	0.476	<0.001***	<0.001***	0.445	0.801	0.372	0.323	0.498
					1.0	0.6
	hemipterous	Exon	A → S	0.476	0.215	0.981	0.847	0.520	0.758	0.029*	0.997
										5.9
	hemipterous	Exon		0.258	0.973	0.981	0.732	0.123	0.168	0.029*	0.997
										6.2
	Tak1	Intron		0.258	0.973	0.404	0.775	<0.001***	<0.001***	0.304	0.417
								0.8	0.5
	TRAF3	Exon		0.999	<0.001***	<0.001***	0.283	0.393	0.042*	0.000***	0.997
					1.0	0.0			0.1	6.2
Secreted	outstretched	Exon	A → S	0.404	0.973	0.521	0.117	<0.001***	<0.001***	0.850	<0.001***
								0.8	0.4		1.1
	upd2	Exon		0.999	0.356	0.536	0.067*	0.633	0.140	0.925	0.731
							0.4
	upd3	Intergenic		0.306	<0.001***	<0.001***	<0.001***	0.336	<0.001***	0.123	<0.001***
					0.4	0.2	0.4		0.2		0.9
Iron metabolism	Tsf1	Exon		0.999	<0.001***	0.012*	0.912	0.814	0.906	0.151	0.997
					0.9	0.4
Hematopoesis	lozenge	Exon		0.306	<0.001***	0.688	0.092*	<0.001***	<0.001***	<0.001***	0.997
					1.0		0.6	1.2	0.8	7.7
	Pvf1	5′-UTR		0.999	0.973	0.981	0.851	0.135	0.443	0.987	0.037*
											0.6
	Pvf1	Exon		0.043*	0.120	<0.001***	0.832	0.633	0.890	0.987	0.731
				1.5		0.9
	Pvf1	Exon		0.000***	0.221	<0.001***	0.065*	0.829	0.271	0.487	0.034*
				0.5		0.3	0.3				0.7
	Pvf1	Intron		0.453	0.226	0.134	0.445	0.109	0.028*	0.808	0.997
									0.0
	Rps6	Exon		0.999	0.951	0.981	0.820	0.000***	0.017*	0.987	0.037*
								0.6	0.2		1.0
Serine protease	Ser7	Intergenic		0.999	<0.001***	0.022*	0.117	<0.001***	0.833	0.029*	<0.001***
					0.2	0.1		0.4		6.2	0.9

q-values are shown for SNPs that associate with at least one load phenotype (on the basis of having FDR q < 0.1). Percentage of total phenotypic variance explained is shown for each SNP with q < 0.1 (below q-value). Change is the amino acid change associated with SNP, where applicable. Sixty-nine of 88 SNPs show no association with load phenotypes with q < 0.1. *q < 0.1, ***q < 0.001. Ef, E. faecalis; Sm, S. marcescens.