Table 1.
Demographics of patients and distribution of FAS genotypes
| Characteristic | GG (N=347) | GA (N=81) | AA (N=12) | GG vs GA |
GA vs AA |
GG vs AA |
||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | % | N | % | N | % | P | P | P | ||
| Age: median & range (yrs) | 9.4 | (0.01 – 20.9) | 11.5 | (0.47 – 19.0) | 10.1 | (1.64 – 16.2) | 0.12 | 0.99 | 0.50 | |
| WBC: median & range | 20600 | (1000 –860000) | 18400 | (300 – 373300) | 17700 | (1500 –848000) | 0.67 | 0.52 | 0.38 | |
| Study | ||||||||||
| CCG-2941 | 30 | 9% | 6 | 7% | 0 | 0% | 0.89 | 1.00 | 0.61 | |
| CCG-2961 | 317 | 91% | 75 | 93% | 12 | 100% | ||||
| Gender | ||||||||||
| Male | 189 | 55% | 49 | 61% | 6 | 50% | 0.39 | 0.54 | 0.99 | |
| Female | 158 | 45% | 32 | 39% | 6 | 50% | ||||
| Race | ||||||||||
| White | 246 | 71% | 54 | 67% | 6 | 50% | 0.52 | 0.34 | 0.19 | |
| Black | 31 | 9% | 4 | 5% | 1 | 8% | 0.34 | 0.51 | 1.00 | |
| Hispanic | 49 | 14% | 18 | 22% | 1 | 8% | 0.10 | 0.45 | 1.00 | |
| Asian | 5 | 1% | 4 | 5% | 4 | 33% | 0.07 | 0.01 | <0.01 | |
| Other | 15 | 4% | 1 | 1% | 0 | 0% | 0.33 | 1.00 | 1.00 | |
| Unknown | 1 | 0 | 0 | |||||||
| Response at end of first course |
||||||||||
| Remission | 290 | 87% | 71 | 90% | 12 | 100% | 0.55 | 0.59 | 0.38 | |
| PD | 23 | 7% | 7 | 9% | 0 | 0% | 0.71 | 0.59 | 1.00 | |
| Die | 22 | 7% | 1 | 1% | 0 | 0% | 0.10 | 1.00 | 1.00 | |
| W/D or unevaluable | 12 | 2 | 0 | |||||||