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time-course of dopamine uptake inhibition and evoked dopamine release after cocaine administration Changes in apparent Km (filled circles) and DAp (open squares) following administration of cocaine (15 mg/kg, i.p.) are shown over 2 hours. Data are expressed as means ± SEM. Maximal apparent Km (1006.2 nM ± SEM 23.0) and DAp (182.4 nM ± SEM 36.9) occurred 20 minutes following cocaine administration.
