Figure 2.

Relative expression of oxidant-related genes in small airway epithelium compared to alveolar macrophages from the same healthy nonsmokers and healthy smokers. Presented only are those oxidant-related genes expressed (Affymetrix detection call of present in >50% of small airway epithelium or alveolar macrophages) in healthy nonsmokers or healthy smokers. Average relative expression of oxidant-related genes in small airway epithelium is presented on the ordinate and average relative expression of oxidant-related genes in alveolar macrophages is presented on the abscissa. Each point represents one gene. white circle = average expression in healthy nonsmokers; black circle = average relative expression in healthy smokers. The different categories of oxidant-related genes surveyed are presented in panels A-H. A. Glutathione metabolism; B. Redox balance; C. Catalase/superoxide dismutases; D. Other oxidant scavengers; E. Pentose pathway cycle; F. Xenobiotic metabolism; G. Selenium-related; and H. Bilirubin/ascorbic acid related.