Table 1.
Study Population for Paired Small Airway Epithelium and Alveolar Macrophage Samples1
| Parameter | Healthy nonsmokers | Healthy smokers |
|---|---|---|
| Demographics | ||
| n | 19 | 30 |
| Sex (male/female) | 15/4 | 22/8 |
| Age (yr) | 42 ± 2 | 43 ± 1 |
| Race (B/W/H/)2 | 11/6/2 | 18/10/2 |
| Smoking history (pack-yr) | 0 | 27 ± 3 |
| Urine nicotine (ng/ml) | Negative | 775 ± 176 |
| Urine cotinine (ng/ml) | Negative | 969 ± 136 |
| Venous CO-Hb3 | 0.7 ± 0.2 | 2.3 ± 0.4 |
| Pulmonary function parameters4 | ||
| FVC | 107 ± 2 | 110 ± 2 |
| FEV1 | 100 ± 6 | 110 ± 2 |
| FEV1/FVC | 80 ± 1 | 82 ± 1 |
| TLC | 97 ± 2 | 100 ± 2 |
| DLCO | 94 ± 2 | 100 ± 2 |
| Small airway epithelium | ||
| Total number recovered ×106 | 5.1 ± 0.4 | 6.7 ± 0.4 |
| % epithelial | 99 ± 1 | 99 ± 1 |
| % inflammatory | 1 ± 1 | 0 |
| Epithelial cell differential | ||
| % ciliated | 73 ± 2 | 76 ± 2 |
| % secretory | 9 ± 1 | 8 ± 1 |
| % basal | 13 ± 2 | 12 ± 1 |
| % undifferentiated | 5 ± 1 | 5 ± 1 |
| Alveolar macrophages | ||
| Total number recovered ×106 | 14 ± 1 | 32 ± 12 |
| % alveolar macrophages after purification | >97% | >98% |
1 Data are presented as mean ± standard error.
2 B = Black W = White H = Hispanic.
3 Venous carboxyhemoglobin, a secondary marker of current smoking; nonsmokers <1.5%.
4 FVC = forced vital capacity; FEV1 = forced expiratory volume in first second; DLCO = diffusion capacity for carbon monoxide; all data presented as % predicted except for FEV1/FVC presented as % observed.