Table 4.

TaqMan RT-PCR Confirmation of Smoking Responsive Genes in Small Airway Epithelium and Alveolar Macrophages

Small airway epithelium			Alveolar macrophages
Gene	Fold-change1	p value2	Gene	Fold-change	p value
Alcohol dehydrogenase 7	6.2	< 0.02	Superoxide dismutase 2	-3.6	< 0.03
Glutathione peroxidase 2	3.9	< 0.01	Glutamate cysteine ligase C	3.8	< 0.01
Metallothionein 1F	-2.3	< 0.05	Protein kinase C alpha	4.2	< 0.01
Cytochrome P450 1B1	36.7	< 0.03

¹ Fold change is calculated as the average expression level in healthy smokers (n = 6) compared to the average expression level in healthy nonsmokers (n = 6).

² p value calculated using an unpaired t test assuming unequal variance.