Table 2.
Genes common with main breast cancer genes signatures
| 28 genes common with the intrinsec genes list (Sorlie et al.) | ||
|---|---|---|
| P value | Gene symbol | Descriptor |
| 0.0003 | FGFR4 | Fibroblast growth factor receptor 4 |
| 0.0007 | SELENBP1 | Selenium binding protein 1 |
| 0.0010 | POSTN | Periostin, osteoblast specific factor |
| 0.0010 | CALU | Calumenin |
| 0.0012 | SERPINH1 | Serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) |
| 0.0012 | KDELR3 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 |
| 0.0013 | PTMS | Parathymosin |
| 0.0013 | HIST2H2BE | Histone 2, H2be |
| 0.0015 | TUSC3 | Tumor suppressor candidate 3 |
| 0.0016 | ZNF516 | Zinc finger protein 516 |
| 0.0018 | BMI1 | Polycomb group ring finger 4 |
| 0.0024 | ACAD11 | Putative acyl-CoA dehydrogenase |
| 0.0026 | INPP4B | Inositol polyphosphate-4-phosphatase, type II, 105 kDa |
| 0.0033 | ESR1 | Estrogen receptor 1 |
| 0.0037 | ACAA2 | Myosin VB |
| 0.005 | CYB5A | Cytochrome b-5 |
| 0.005 | CLIP4 | CAP-GLY domain containing linker protein family, member 4 |
| 0.0051 | AYTL1 | Hypothetical protein FLJ20481 |
| 0.0056 | RALGPS1 | Ral GEF with PH domain and SH3 binding motif 1 |
| 0.0062 | PSMB10 | Proteasome (prosome, macropain) subunit, beta type, 10 |
| 0.0067 | LRBA | LPS-responsive vesicle trafficking, beach and anchor containing |
| 0.0070 | UBE1 | Ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing) |
| 0.0084 | FBP1 | Fructose-1,6-bisphosphatase 1 |
| 0.0087 | COL6A3 | Collagen, type VI, alpha 3 |
| 0.0087 | TM9SF2 | Transmembrane 9 superfamily member 2 |
| 0.0090 | TAP1 | Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) |
| 0.0097 | DIP2B | KIAA1463 protein |
| 0.0100 | TncRNA | Trophoblast-derived noncoding RNA |
| 24 genes common with wound healing signature (Chang et al) | ||
| 0.0038 | EIF4G1 | Eukaryotic translation initiation factor 4 gamma, 1 |
| 0.0086 | PRIM2 | primase, polypeptide 2A, 58 kDa |
| 0.0021 | POR | P450 (cytochrome) oxidoreductase |
| 0.0002 | FANCG | Fanconi anemia, complementation group G |
| 0.0097 | EXOSC7 | Exosome component 7 |
| 0.0006 | FDPS | Farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) |
| 0.0020 | C5orf4 | Chromosome 5 open reading frame 4 |
| 0.0055 | CDCA4 | Cell division cycle associated 4 |
| 0.0099 | H2AFV | H2A histone family, member V |
| 0.0061 | FABP3 | Fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) |
| 0.0027 | CKLF | Chemokine-like factor |
| 0.0014 | MGC4308 | Hypothetical protein MGC4308 |
| 0.0009 | FADS1 | Fatty acid desaturase 1 |
| 0.0061 | SFTPB | Surfactant, pulmonary-associated protein B |
| 0.0055 | PLA2R1 | Phospholipase A2 receptor 1, 180 kDa |
| 0.0007 | SELENBP1 | Selenium binding protein 1 |
| 0.006 | FARSB | Phenylalanine-tRNA synthetase-like, beta subunit |
| 0.0054 | MEF2D | MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D) |
| 0.0029 | NUTF2 | Nuclear transport factor 2 |
| 0.0098 | ID3 | Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein |
| 0.0087 | ID2 | Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
| 0.0069 | PRG2 | Proteoglycan 2, bone marrow |
| 0.0001 | H2AFX | H2A histone family, member X |
| 0.0047 | WSB1 | WD repeat and SOCS box-containing 1 |
| 17 genes common with new intrinsic gene list (Zhiyan et al.) | ||
| 0.0033 | TRIM33 | Tripartite motif-containing 33 |
| 0.0003 | RAB5C | RAB5C, member RAS oncogene family |
| 0.0086 | PRIM2 | primase, polypeptide 2A, 58 kDa |
| 0.0071 | RAB21 | RAB21, member RAS oncogene family |
| 0.0029 | SSTK | Serine/threonine protein kinase SSTK |
| 0.0001 | ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 |
| 0.0052 | IRF4 | Interferon regulatory factor 4 |
| 0.0067 | LRBA | LPS-responsive vesicle trafficking, beach and anchor containing |
| 0.0036 | IL13RA1 | Interleukin 13 receptor, alpha 1 |
| 0.0033 | ESR1 | Estrogen receptor 1 |
| 0.0017 | MFAP2 | Microfibrillar-associated protein 2 |
| 0.0031 | STAT1 | Signal transducer and activator of transcription 1, 91 kDa |
| 0.0013 | PPFIA1 | Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 |
| 0.0061 | MYO1C | Myosin IC |
| 0.0082 | PPFIA4 | Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 |
| 0.0060 | RAB31 | RAB31, member RAS oncogene family |
| 0.0026 | INPP4B | Inositol polyphosphate-4-phosphatase, type II, 105 kDa |
| 2 genes common with Recurrence Score genes (Paik et al) | ||
| 0.0033 | ESR1 | Estrogen receptor 1 |
| 0.0021 | MMP11 | Matrix metalloproteinase 11 (stromelysin 3) |