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. 2009 Dec 18;5(12):e1000616. doi: 10.1371/journal.pcbi.1000616

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Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) the signal strengths (measured by the correlation between the latent regulators and their downstream genes); (B) the performances of different methods when there was no systematic noise; (C) moderate systematic noises (measured by the correlation between genes and systematic noises); (D) the performances of different methods when the systematic noises were as shown in (C); (E) stronger systematic noises than (C); (F) the performances of different methods when the systematic noises were as shown in (E). FEM Fisher-Z: the fixed effect model based on Fisher-Z transformation; REM Fisher-Z: the random effect model based on Fisher-Z transformation; Combine P-value: combine p-values of Fisher's Inverse tests; Order Statistic: Order-based non-parametric meta-analysis; d-statistics: the semi-parametric meta-analysis. See Materials and Methods section for details of individual methods.

Inline graphic — (A) the signal strengths (measured by the correlation between the latent regulators and their downstream genes); (B) the performances of different methods when there was no systematic noise; (C) moderate systematic noises (measured by the correlation between genes and systematic noises); (D) the performances of different methods when the systematic noises were as shown in (C); (E) stronger systematic noises than (C); (F) the performances of different methods when the systematic noises were as shown in (E). FEM Fisher-Z: the fixed effect model based on Fisher-Z transformation; REM Fisher-Z: the random effect model based on Fisher-Z transformation; Combine P-value: combine p-values of Fisher's Inverse tests; Order Statistic: Order-based non-parametric meta-analysis; d-statistics: the semi-parametric meta-analysis. See Materials and Methods section for details of individual methods.