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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: J Dermatol Sci. 2009 Nov 3;56(3):141–147. doi: 10.1016/j.jdermsci.2009.10.001

Figure 1.

Figure 1

L-selectin-mediated leukocyte recruitment. The initial capture of free-flowing leukocytes is mediated by L-selectin on leukocytes binding to endothelial ligands constitutively expressed on HEV, inflamed vessels, or on previously adhered leukocytes (secondary tethering). L-selectin alone mediates fast rolling, but synergistic interactions between L-selectin and integrin functions slow the rolling velocity of the leukocyte, facilitating activation by chemoattractants (e.g., chemokines) presented on the endothelium. Leukocyte activation (through L-selectin ligation and chemokines) induces high affinity integrin-mediated firm adhesion. Ultimately, the leukocyte transmigrates through the vascular endothelium and into the tissue. PAF, platelet-activating factor; CXCR4, CXC chemokine receptor 4.