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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: J Dermatol Sci. 2009 Nov 3;56(3):141–147. doi: 10.1016/j.jdermsci.2009.10.001

Table 1.

L-selectin ligands

Name Expression Comments
GlyCAM-1a HEV PNAd subgroup, secreted
Sgp200 HEV PNAd subgroup, membrane bound and
secreted forms
CD34 Vascular endothelium
(including HEV)		 PNAd subgroup, non-reactive forms in non-
HEV and non-inflamed vessels
Podocalyxin Vascular endothelium
(including HEV)		 PNAd subgroup, non-reactive forms in non-
HEV and non-inflamed vessels
Endomucin Vascular endothelium
(including HEV)		 PNAd subgroup, non-reactive forms in non-
HEV and non-inflamed vessels
Nepmucin HEV, some leukocytes PNAd subgroup, can also mediate binding
through Ig domain
MAdCAM-1 HEV, intestinal lamina
propria		 Primarily mediates α4β7 integrin binding
through Ig domain, L-selectin binding
mediated by tissue-specific glycosylation
Endoglycan Leukocytes, vascular
endothelium		 Selectin binding similar to PSGL-1
PSGL-1 Leukocytes Binds L-, P-, and E-selectin through
overlapping regions, mediates secondary
tethering
CLA Inflamed endothelium,
lymphocyte subsets		 Defined by HECA-452 mAb, expressed on
skin-homing lymphocytes
a

GlyCAM-1, glycosylation dependent cell adhesion molecule-1; HEV, high endothelial venule; PNAd, peripheral node addressins; Ig, immunoglobulin; MAdCAM-1, mucosal addressin cell adhesion molecule-1; PSGL-1, P-selectin glycoprotein ligand-1; CLA, cutaneous lymphocyte-associated antigen.