Table 3.
Associations of obesity and body composition with change in GFR estimated using the MDRD Study equation
| Annualized change in eGFR | Rapid decline in eGFR* (dichotomous outcome) |
|||
|---|---|---|---|---|
| Measurement | Adjusted** difference ± SD |
Adjusted† difference ± SD |
Adjusted** odds ratio (95% CI) |
Adjusted† odds ratio (95% CI) |
| Body mass index (kg/m2) | ||||
| < 25.0 | 0.00 (Ref) | 0.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
| 25.0–29.9 | −0.27 ± 5.22 | −0.12 ± 5.22 | 1.21 (1.00, 1.46) | 1.11 (0.92, 1.35) |
| ≥ 30.0 | −0.39 ± 4.38 | −0.08 ± 4.53 | 1.56 (1.25, 1.95) | 1.22 (0.97, 1.54) |
| Per 5 kg/m2† | −0.16 ± 4.00 | −0.03 ± 4.13 | 1.19 (1.09, 1.30) | 1.08 (0.99, 1.18) |
| P† | 0.01 | 0.5 | 0.001 | 0.2 |
| Waist circumference (cm) | ||||
| <82 (w); <92 (m) | 0.00 (Ref) | 0.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
| 82–91 (w); 92–96 (m) | −0.55 ± 5.02 | −0.47 ± 5.02 | 1.38 (1.08, 1.76) | 1.29 (1.01, 1.65) |
| 92–100 (w); 97–103 (m) | −0.34 ± 5.00 | −0.22 ± 5.00 | 1.28 (1.00 (1.64) | 1.16 (0.90, 1.49) |
| ≥101 (w); ≥103 (m) | −0.64 ± 5.01 | −0.36 ± 5.14 | 1.82 (1.44, 2.31) | 1.46 (1.14, 1.86) |
| Per 12 cm† | −0.20 ± 3.53 | −0.09 ± 3.67 | 1.25 (1.16, 1.36) | 1.15 (1.06, 1.25) |
| P† | <0.001 | 0.09 | 0.01 | 0.02 |
| Fat mass (kg) | ||||
| <28 (w); <45 (m) | 0.00 (Ref) | 0.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
| 28–33 (w); 25–30 (m) | 0.03 ± 5.05 | 0.09 ± 5.01 | 0.98 (0.77, 1.25) | 0.93 (0.73, 1.19) |
| 34–41 (w); 31–36 (m) | −0.39 ± 5.08 | −0.28 ± 5.08 | 1.35 (1.07, 1.71) | 1.23 (0.97, 1.56) |
| >41 (w); >36 (m) | −0.23 ± 5.08 | 0.05 ± 5.21 | 1.36 (1.08, 1.72) | 1.09 (0.86, 1.40) |
| Per 10 kg† | −0.11 ± 3.60 | −0.01 ± 3.67 | 1.14 (1.05, 1.24) | 1.02 (0.98, 1.06) |
| P† | 0.04 | 0.7 | 0.003 | 0.3 |
*
Rapid decline in eGFR defined as loss exceeding 3 mL/min/1.73m2/year.
**
Adjusted for age, sex, race, and smoking.
†
Additionally adjusted for diabetes, hypertension and C-reactive protein. Estimated glomerular filtration rate (eGFR) is expressed in mL/min/1.73 m^2 and is calculated from serum creatinine using the 4-variable MDRD (Modification of Diet in Renal Disease) Study equation. SD = standard deviation. CI = confidence interval. Evaluated as a continuous, linear exposure.
Abbreviation: ref, reference.