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. Author manuscript; available in PMC: 2010 Dec 3.
Published in final edited form as: FEBS Lett. 2009 Oct 29;583(23):3811–3816. doi: 10.1016/j.febslet.2009.10.075

Figure 1.

Figure 1

Sorting of retrograde cargoes in endosomes. MPRs (red bars) and toxins (green spheres) are present in early endosomes and are sorted in that compartment prior to delivery to the Golgi complex. The toxins are directed towards Rab11-containing recycling endosomes prior to arrival at the Golgi. Rabs 21 and 22 may also play a role at this location [9]. MPRs are sorted towards Rab7 and Rab9-compartments. Both cargoes use Retromer as they leave early endosomes. Because toxins use recycling endosomes, and retromer depletion accumulates toxins in early endosomes, the presumed step is at early endosome exit. Similarly, for MPRs, exit from early endosomes is the presumed site of retromer function. Distinct Golgins and SNARE complexes at the TGN participate in vesicle receipt. This includes the GARP complex [65]. See text for additional details.