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. Author manuscript; available in PMC: 2010 Dec 10.
Published in final edited form as: Exp Cell Res. 2009 Apr 21;315(20):3477–3485. doi: 10.1016/j.yexcr.2009.04.005

Figure 3. Arginine and Leucine residues are important for PARG MTS function.

Figure 3

The putative PARG MTS sequence and exon structure is indicated at top left as in Fig. 2. Side-directed mutagenesis was utilized to identify amino acids essential for MTS function. Different arginine to alanine mutations are shown in mutants 6 to 11 and leucine to aspartate mutants are shown in mutants 12 to 14. Analysis of PARG using anti-V5 antibody and quantification were completed as described in Fig. 2.