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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Clin Cancer Res. 2009 Nov 24;15(23):7246–7255. doi: 10.1158/1078-0432.CCR-09-1292

Figure 4.

Figure 4

MSC protect measles virus from complete neutralization by anti-measles antibody in mice. (A) Timeline for decay of human measles immune serum in sera of athymic mice over time. Mice were euthanized at each time point to obtain serum for virus plaque reduction neutralization (PRN) assays. Each point is the average of PRN assays from 2 to 4 mice. Curve fit R2=0.99. (B) Representative photographs showing correlation between tumor location (indicated by GLuc activity) and MV-Luc gene expression (FLuc activity), delivered by cell-free virus or MSC-associated virus in measles naïve or measles immune mice. Mice were imaged using colenterazine substrate for GLuc expression one day before imaging for FLuc activity using D-luciferin substrate. The photons count (photons/sec) for each mouse is as indicated.