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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Clin Cancer Res. 2009 Nov 24;15(23):7246–7255. doi: 10.1158/1078-0432.CCR-09-1292

Figure 5.

Figure 5

MSC mediated delivery of measles virus enhanced survival of measles immune mice. (A) Kaplan Meier survival curves of mice given different treatments; saline, uninfected MSC, 105 TCID50 `naked' MV-NIS or 105 MV-NIS infected MSC (MOI 4.0, ~ 60% infection) in measles naïve mice (−Ab) or measles immune mice (+Ab, 100 EU/mouse). (B) Immunohistochemical staining for measles-nucleocapsid (MV-N) protein (blue staining=site of viral gene expression) and CD68 positive macrophages (brown/red staining). Arrows in the last panel point to corresponding necrotic area in the tumor with minimal MV-N staining but strong CD68 staining. Scale bars indicate 500 μm.

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