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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Nat Genet. 2009 Nov 15;41(12):1308–1312. doi: 10.1038/ng.487

Figure 3.

Figure 3

Expression quantitative trait loci across the MAPT locus measured in 133 human frontal cortex samples; panel A shows association between genotypes and transcript levels across the MAPT locus. In this analysis the allelic load at genotyped polymorphisms across the locus is tested for association with transcript levels of each gene across the locus. The results of the analysis are shown as log transformed p values color-coded to match the transcript of interest. Notably genotypes across this locus are associated with MAPT (pink) and LRRC37A (blue) levels. Boxplots in panels B and C illustrate a dose relationship between allele load at the most significantly associated PD SNP (rs393152) and expression of MAPT (B) and LRRC37A (C), p values 4.1×10−6 and 1.7×10−13 respectively. Notably, the allele associated with higher risk for PD, A, is associated with high levels of MAPT expression and low levels of LRRC37A expression.