Table 1.
Top 50 Differentially Expressed TNFα-Inducible Genes Specifically Sensitive to DC Treatment
| |
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Fold change control vs. treatments |
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|---|---|---|---|---|---|
| Probe set ID | Gene title | Gene symbol | TNF alone | DC + TNF | C95 + TNF |
| 211122_s_at | Chemokine (C-X-C motif) ligand 11 | CXCL11 | 786.1 | 248 | 608.6 |
| 211506_s_at | Interleukin 8 | IL8 | 415.3 | 307.3 | 422.3 |
| 203868_s_at | Vascular cell adhesion molecule 1 | VCAM1 | 414.2 | 306.9 | 394 |
| 204533_at | Chemokine (C-X-C motif) ligand 10 | CXCL10 | 318.6 | 141.2 | 320.7 |
| 215078_at | Superoxide dismutase 2, mitochondrial | SOD2 | 202.8 | 70.5 | 84.3 |
| 202859_x_at | Interleukin 8 | IL8 | 168.3 | 153.6 | 170.8 |
| 207517_at | Laminin, gamma 2 | LAMC2 | 117.1 | 61.1 | 66.5 |
| 204439_at | interferon-induced protein 44-like | IFI44L | 84.1 | 34.3 | 102.9 |
| 228617_at | XIAP-associated factor 1 | XAF1 | 81.8 | 26.8 | 72.6 |
| 204580_at | Matrix metallopeptidase 12 (macrophage elastase) | MMP12 | 80.5 | 52 | 68.3 |
| 205599_at | TNF receptor-associated factor 1 | TRAF1 | 78 | 5 | 64 |
| 205828_at | Matrix metallopeptidase 3 (stromelysin 1, progelatinase) | MMP3 | 60.4 | 34.2 | 38.6 |
| 210229_s_at | Colony-stimulating factor 2 (granulocyte-macrophage) | CSF2 | 57.3 | 54.2 | 55 |
| 235116_at | TNF receptor-associated factor 1 | TRAF1 | 53.3 | 33.3 | 41.8 |
| 221371_at | Tumor necrosis factor (ligand) superfamily, member 18 | TNFSF18 | 48.1 | 35.4 | 45.5 |
| 219181_at | Lipase, endothelial | LIPG | 44.3 | 19.6 | 28.6 |
| 223484_at | Chromosome 15 open reading frame 48 | C15orf48 | 42.2 | 23.8 | 31.3 |
| 232593_at | likely orthologue of mouse lung-inducible neutralized-related C3HC4 RING domain Protein | LINCR | 36.9 | 17.4 | 30.1 |
| 202643_s_at | Tumor necrosis factor, α-induced protein 3 | TNFAIP3 | 35.8 | 23.3 | 31 |
| 216841_s_at | Superoxide dismutase 2, mitochondrial | SOD2 | 35.7 | 20.4 | 24.6 |
| 204475_at | Matrix metallopeptidase 1 (interstitial collagenase) | MMP1 | 34.5 | 21.4 | 24.2 |
| 216598_s_at | Chemokine (C-C motif) ligand 2 | CCL2 | 33.3 | 32.1 | 32 |
| 202644_s_at | Tumor necrosis factor, α-induced protein 3 | TNFAIP3 | 33.2 | 21.9 | 27.7 |
| 214974_x_at | Chemokine (C-X-C motif) ligand 5 | CXCL5 | 33.1 | 23.5 | 25.4 |
| 217767_at | Complement component 3 | C3 | 31.9 | 19.9 | 33.3 |
| 210538_s_at | Baculoviral IAP repeat-containing 3 | BIRC3 | 31.4 | 24.6 | 32.7 |
| 230966_at | Interleukin 4-induced 1 | IL4I1 | 30.8 | 18.7 | 24.9 |
| 205680_at | Matrix metallopeptidase 10 (stromelysin 2) | MMP10 | 30.7 | 19.4 | 26.2 |
| 218182_s_at | Claudin 1 | CLDN1 | 26.1 | 20.4 | 21.5 |
| 215485_s_at | Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | ICAM1 | 28.8 | 19.8 | 26 |
| 204655_at | Chemokine (C-C motif) ligand 5 | CCL5 | 28.5 | 14.6 | 30.6 |
| 1405_i_at | Chemokine (C-C motif) ligand 5 | CCL5 | 27.9 | 17.5 | 28.7 |
| 204994_at | Myxovirus (influenza virus) resistance 2 (mouse) | MX2 | 27.1 | 11.1 | 26.2 |
| 204470_at | Chemokine (C-X-C motif) ligand 1 (melanoma growth-stimulating activity, alpha) | CXCL1 | 26.9 | 21 | 28.2 |
| 222549_at | Claudin 1 | CLDN1 | 26.1 | 22.5 | 22.5 |
| 202086_at | Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | MX1 | 25.1 | 12.4 | 22.6 |
| 202376_at | Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | SERPINA3 | 24.9 | 17.4 | 29.2 |
| 1555759_a_at | Chemokine (C-C motif) ligand 5 | CCL5 | 23.6 | 16.5 | 26 |
| 221085_at | Tumor necrosis factor (ligand) superfamily, member 15 | TNFSF15 | 22.3 | 10 | 15.5 |
| 203236_s_at | Lectin, galactoside-binding, soluble, 9 (galectin 9) | LGALS9 | 22.3 | 8.7 | 19.3 |
| 204933_s_at | Tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) | TNFRSF11B | 22.3 | 15 | 19.5 |
| 207339_s_at | Lymphotoxin beta (TNF superfamily, member 3) | LTB | 22.1 | 15.1 | 15.7 |
| 228607_at | 2′ −5′-oligoadenylate synthetase 2, 69/71 kDa | OAS2 | 21.7 | 10 | 16.1 |
| 215223_s_at | Superoxide dismutase 2, mitochondrial | SOD2 | 21.3 | 18.7 | 21.4 |
| 203828_s_at | Interleukin 32 | IL32 | 20.4 | 14.8 | 17.9 |
| 221477_s_at | Hypothetical protein MGC5618 | MGC5618 | 20.3 | 16 | 17.1 |
| 202267_at | Laminin, gamma 2 | LAMC2 | 19.7 | 11.7 | 15.1 |
| 202638_s_at | Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | ICAM1 | 18.4 | 14.7 | 16.9 |
| 202510_s_at | Tumor necrosis factor, α-induced protein 2 | TNFAIP2 | 18.2 | 15.3 | 17.2 |
| 223502_s_at | Tumor necrosis factor (ligand) superfamily, member 13b | TNFSF13B | 17.6 | 7.6 | 16.6 |
Data presented indicate fold change in gene expression compared with TNF-α-untreated control group. Probe set ID, Affymetrix probe identifications. Genes in bold font were verified by using quantitative PCR or protein analysis studies. Supplement for Fig. 8, cluster B.