Skip to main content
. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Trends Biochem Sci. 2009 Oct 12;34(12):640–647. doi: 10.1016/j.tibs.2009.07.008

Figure 4.

Figure 4

Models of recruitment of deadenylases onto mRNAs.

(a) a translation-dependent exchange of eRF3 for the PAM2-containing PAN3 (purple) factor on PABP (red) allows the recruitment of the PAN2 deadenylase (blue) and initiation of deadenylation.

(b) Expression of the PAM2-containing TOB1 (pink) recruits the CCR4-CAF1 (aqua–blue) deadenylases onto mRNA possibly bypassing PAN2 and activating deadenylation.

(c) Expression of BTG2 (pink) activates CAF1-dependent deadenylation by an unknown mechanism.

HHS Vulnerability Disclosure