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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Med Hypotheses. 2009 Aug 28;74(1):63–66. doi: 10.1016/j.mehy.2009.08.002

Figure 1.

Figure 1

This figure schematizes our hypothesis: Erythrocytes lyse and release their hemoglobin after ICH. Heme is liberated from hemoglobin and is converted into UBR and BOXes. UBR and BOXes activate microglia and astrocytes, leading to the release of cytokines and chemokines and subsequent activation of the endothelium and trafficking of leukocytes into the brain parenchyma. Activated leukocytes, glia and cytokines then contribute to brain injury.