Table 6.

Odds ratio (95% CI) of fracture according to levels of sex steroid hormone at baseline: all fractures main effects.

			Model 1 Base Modela		Model 2 Additional Adjustment for BMI		Model 3 Full MV Modelb
All Fracture	Cases	Controls	OR (95% CI) for fracture	p trend	OR (95% CI) for fracture	p trend	OR (95% CI) for fracture	p trend
Total Estradiol (pg/ml)				0.170		0.256		0.213
≤6	209	179	1.00		1.00		1.00
>6 – 10	184	213	0.73 (0.55, 0.97)		0.76 (0.57, 1.01)		0.74 (0.56, 0.99)
>10 – 14	147	140	0.90 (0.66, 1.22)		0.94 (0.69, 1.29)		0.93 (0.68, 1.28)
>14	163	172	0.80 (0.60, 1.08)		0.87 (0.63, 1.18)		0.88 (0.64, 1.20)
Free Estradiol (pg/ml)				0.163		0.300
≤0.16	218	185	1.00		1.00		1.00	0.296
>0.16 – 0.24	152	176	0.73 (0.54, 0.98)		0.75 (0.56, 1.04)		0.75 (0.55, 1.01)
>0.24 – 0.39	170	167	0.86 (0.65, 1.15)		0.91 (0.67, 1.22)		0.89 (0.66, 1.20)
>0.39	163	176	0.78 (0.58, 1.04)		0.85 (0.62, 1.17)		0.86 (0.63, 1.19)
Bioavailable E2 (pg/ml)				0.243		0.384		0.389
≤4.0	230	202	1.00		1.00		1.00
>4.0+ – 6.1	131	153	0.75 (0.55, 1.01)		0.77 (0.57, 1.04)		0.77 (0.56, 1.04)
>6.1 – 9.9	180	175	0.90 (0.68, 1.20)		0.95 (0.71, 1.27)		0.93 (0.70, 1.25)
>9.9	162	174	0.81 (0.60, 1.08)		0.89 (0.65, 1.22)		0.91 (0.66, 1.24)
SHBG (µg/dl)				0.026		0.067		0.048
≤0.87	155	188	1.00		1.00		1.00
>0.87–1.21	195	187	1.28 (0.95, 1.71)		1.26 (0.93, 1.70)		1.29 (0.95, 1.74)
>1.21–1.67	167	185	1.11 (0.82, 1.50)		1.08 (0.79, 1.48)		1.12 (0.82, 1.53)
>1.67	226	182	1.53 (1.14, 2.06)		1.48 (1.07, 2.04)		1.53 (1.11, 2.12)

^aAdjusted for age, ethnicity, randomization date, fracture history and hysterectomy status.

^bAdditional adjustment for BMI, treated diabetes, self-reported health status.