Table 7.

Odds ratio (95% CI) of fracture according to levels of sex steroid hormone at baseline: hip fractures main effects.

			Model 1 Base Modela		Model 2 Additional Adjustment for BM		Model 3 Full MV Modelb
Hip Fracture	Cases	Controls	OR (95% CI) for fracture	p trend	OR (95% CI) For fracture	p trend	OR (95% CI) for fracture	p trend
Total Estradiol (pg/ml)				0.137		0.354		0.325
≤6	73	50	1.00		1.00		1.00
>6 – 10	57	69	0.57 (0.34, 0.94)		0.63 (0.38, 1.05)		0.63 (0.37, 1.06)
>10 – 14	45	46	0.67 (0.39, 1.16)		0.75 (0.43, 1.31)		0.74 (0.42, 1.31)
>14	43	47	0.62 (0.36, 1.08)		0.83 (0.46, 1.48)		0.89 (0.49, 1.61)
Free Estradiol (pg/ml)				0.027		0.188		0.271
≤ 0.16	78	49	1.00		1.00		1.00
>0.16 – 0.24	50	63	0.50 (0.30, 0.84)		0.55 (0.33, 0.94)		0.58 (0.34, 1.00)
>0.24 – 0.39	56	56	0.63 (0.37, 1.05)		0.77 (0.45, 1.31)		0.75 (0.43, 1.30)
> 0.39	34	44	0.48 (0.27, 0.86)		0.72 (0.38, 1.35)		0.77 (0.40, 1.47)
Bioavailable E2 (pg/ml)				0.056		0.404		0.496
≤ 4.0	82	55	1.00		1.00		1.00
>4.0+ – 6.1	45	54	0.56 (0.33, 0.94)		0.63 (0.37, 1.08)		0.65 (0.38, 1.13)
>6.1+ – 9.9	57	58	0.66 (0.40, 1.08)		0.80 (0.47, 1.35)		0.78 (0.46, 1.33)
> 9.9	34	45	0.50 (0.28, 0.89)		0.75 (0.40, 1.39)		0.80 (0.42, 1.50)
SHBG (µg/dl)				<0.001		0.004		0.002
≤ 0.87	22	52	1.00		1.00		1.00
> 0.87–1.21	52	60	2.14 (1.14, 4.03)		1.94 (1.02, 3.70)		2.11 (1.08, 4.14)
> 1.21–1.67	66	61	2.64 (1.43, 4.89)		2.28 (1.20, 4.34)		2.69 (1.37, 5.29)
> 1.67	90	53	4.23 (2.28, 7.85)		3.42 (1.74, 6.71)		4.01 (1.98, 8.15)

^aAdjusted for age, ethnicity, randomization date, fracture history and hysterectomy status.

^bAdditional adjustment for BMI, treated diabetes, self-reported health status.