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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Lab Invest. 2009 Oct 19;89(12):1397–1409. doi: 10.1038/labinvest.2009.115

Figure 5. Insulin stimulates oxidative stress in cultured HSCs by increasing the levels of ROS and LPO, which is attenuated by curcumin.

Figure 5

Serum-starved HSCs were stimulated with insulin at indicated concentrations in the absence (A) or presence (B) of curcumin at 0–30μM in serum-free media for 24 hr. The levels of intracellular ROS and LPO were assessed and expressed as fold changes compared to that in cells with no treatment (the 1st column on the left). Values were presented as means ± S.D. (n≥3). *p<0.05, versus cells with no treatment; ‡p<0.05, versus cells treated with insulin only (the 2nd column on the left in B).