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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Lab Invest. 2009 Oct 19;89(12):1397–1409. doi: 10.1038/labinvest.2009.115

Figure 6. Insulin reduces the level of intracellular GSH and the ratio of GSH/GSSG in cultured HSCs, which are dose-dependently eliminated by curcumin.

Figure 6

Serum-starved HSCs were stimulated with insulin at indicated concentrations in the absence (A & C) or presence (B & D) of curcumin at 0–30μM in serum-free media for 24 hr. The levels of total cellular GSH (A & B) and the ratio of GSH/GSSG (C & D) were determined. The levels of total GSH were expressed as nmol/μg protein. Values were presented as means ± S.D. (n≥3). *p<0.05, versus cells with no treatment (the 1st column on the left). ‡p<0.05, versus cells treated with insulin only (the 2nd column on the left in B & D)