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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Acta Biomater. 2009 Aug 4;6(1):39–47. doi: 10.1016/j.actbio.2009.07.041

Figure 3.

Figure 3

Histological sections showing representative 12-week tissue repair at defect sites treated with OPF hydrogel composites containing MSCs and TGF-β1. Sections stained with H&E (a), Safranin O (b), and Masson's trichrome (c) at 2× display a thick fibrous layer at the articular surface and significant restoration in the subchondral region. Small arrows define the edges of the defects. Boxed regions are shown at 10× magnification to illustrate the excessive fibrous tissue growth into the joint surface (d) and remodeling tissue in the subchondral region (e). Bar is 1 mm for (a-c) and 250 μm for (d, e).