Table 3.
Effect of Randomized Aspirin Assignment on Visually Significant AMD by Subgroups.
| |
No. of AMD/Total |
|
|
|
|
|---|---|---|---|---|---|
| |
Aspirin (N=19,716) |
Placebo (N=19,705) |
RR* |
95% CI |
P-value |
| Age, y | |||||
| 45−54 | 9/11,959 | 20/11,948 | 0.46 | 0.21−0.99 | 0.05 |
| 55−64 | 39/5,806 | 39/5,801 | 1.00 | 0.64−1.55 | 0.98 |
| ∃65 |
63/1,951 |
75/1,956 |
0.84 |
0.60−1.17 |
0.30 |
| Smoke Cigarettes | |||||
| Current | 16/2,558 | 25/2,633 | 0.73 | 0.39−1.38 | 0.34 |
| Past/Never |
95/17,143 |
108/17,052 |
0.86 |
0.65−1.14 |
0.29 |
| Alcohol Use | |||||
| <1/wk | 67/11,493 | 88/11,455 | 0.75 | 0.55−1.03 | 0.08 |
| ∃1/wk |
44/8,218 |
46/8,245 |
0.97 |
0.64−1.47 |
0.88 |
| Body-mass index | |||||
| <25.0 | 48/9,803 | 72/9,826 | 0.67 | 0.46−0.96 | 0.03 |
| 25.0−29.9 | 32/5,967 | 36/5,985 | 0.86 | 0.54−1.39 | 0.54 |
| ∃30.0 |
28/3,535 |
25/3,504 |
1.16 |
0.68−2.00 |
0.58 |
| Hypertension | |||||
| Yes | 51/5,093 | 50/5,032 | 0.99 | 0.67−1.46 | 0.94 |
| No |
60/14,617 |
84/14,670 |
0.73 |
0.52−1.01 |
0.06 |
| Hyperlipidemia | |||||
| Yes | 40/5,858 | 53/5,697 | 0.77 | 0.51−1.16 | 0.20 |
| No |
71/13,848 |
81/14,002 |
0.86 |
0.63−1.19 |
0.37 |
| Diabetes | |||||
| Yes | 4/514 | 5/477 | 0.77 | 0.21−2.87 | 0.69 |
| No |
107/19,190 |
129/19,216 |
0.83 |
0.64−1.07 |
0.15 |
| Menopausal status and use of HT | |||||
| Premenopausal | 3/5,456 | 7/5,465 | 0.43 | 0.11−1.65 | 0.22 |
| Uncertain | 7/3,493 | 8/3,595 | 0.89 | 0.32−2.45 | 0.82 |
| Postmenopausal and current HT | 33/5,967 | 44/5,832 | 0.74 | 0.47−1.16 | 0.18 |
| Postmenopausal and no HT |
68/4,752 |
75/4,761 |
0.91 |
0.65−1.26 |
0.56 |
| Parental history of MI before 60 yrs of age | |||||
| Yes | 9/2,299 | 13/2,286 | 0.82 | 0.35−1.92 | 0.64 |
| No |
93/15,381 |
101/15,458 |
0.90 |
0.68−1.19 |
0.46 |
| Multivitamin Use | |||||
| Current | 50/7,155 | 46/7,110 | 1.14 | 0.76−1.70 | 0.53 |
| Past/Never |
61/12,289 |
87/12,313 |
0.68 |
0.49−0.95 |
0.02 |
| Eye exam in past 2 yrs | |||||
| Yes | 97/16,307 | 112/16,276 | 0.86 | 0.66−1.13 | 0.29 |
| No | 14/3,408 | 22/3,423 | 0.64 | 0.33−1.25 | 0.19 |
Abbreviations: AMD, age-related macular degeneration; CI, confidence interval; HT, hormone therapy; MI, myocardial infarction.
*
Adjusted for age and vitamin E and beta carotene treatment assignment.