Fig. 2.
Peripheral sensitization of forelimb primary afferents 35 days following SCI. In vitro recordings from nociceptors demonstrate an increased spontaneous activity compared to naïve and sham animals (A). These units also demonstrate mechanical sensitization evidenced by an increased response to a suprathreshold mechanical stimulation (B) and a decreased threshold to activation (C). Units demonstrate thermal hyperalgesia evidenced by an increased response to thermal stimulation and a decreased threshold to activation (E). Insets in B, C and D show stimulus parameters. *p<0.05, Kruskal-Wallis test followed by a Dunn's post hoc analysis.