Type I but not type II IFN-induced Stat-1 phosphorylation is inhibited by HSV-1. Vero cells were mock infected (lanes 1–3) or infected (MOI = 20) with WT HSV-1 (KOS, lanes 4–6) and treated with IFNα (lanes 2, 5) or IFNγ (lanes 3, 6) for 30 min before harvest. Western blot analysis was done with antibodies to pStat-1, Stat-1, ICP27, and actin.