Figure 6.

ICP27 does not affect the splicing or nuclear export of IFNAR2 transcripts. Vero cells were mock-infected or infected (MOI = 20) with wt HSV-1 (KOS, A: lane 2, B: lanes 3–4) or ICP27⁻ virus (5dl1.2, A: lane 3, B: lanes 5–6) for 10 hours. RNA was harvested from whole cells (A) or cells fractionated into nuclear and cytoplasmic components (B) and Northern blot analysis was done with probes specific for IFNAR2 and U3 snRNA.