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. Author manuscript; available in PMC: 2010 Dec 16.
Published in final edited form as: J Control Release. 2009 Jun 7;140(3):301–305. doi: 10.1016/j.jconrel.2009.05.035

Figure 6. Effect of kininogen deficiency on the thrombogenic activity of SPIONs in tumors.

Figure 6

CREKA-SPIONs nanoparticles were injected into tumor-bearing mice as described in Methods, and the tumor distribution of CREKA-SPIONs was examined 6 h post-injection. Upper images: accumulation of FITC-labeled nanoparticles in the tumors. Lower images: merge of DAPI (nuclei, blue) and fluorescein (nanoparticles, green) fluorescence. In both kininogen-deficient and control mice the entrapment of SPIONs in thrombi in blood vessels (yellow arrows) was observed. Size bar, 200 μm. One representative experiment out of 4 is shown.